2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W040129R
    Chromomycin A3 (Standard) 7059-24-7
    Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe.
    Chromomycin A3 (Standard)
  • HY-W040146R
    Propionylpromazine hydrochloride (Standard) 7681-67-6
    Propionylpromazine (hydrochloride) (Standard) is the analytical standard of Propionylpromazine (hydrochloride). This product is intended for research and analytical applications. Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease.
    Propionylpromazine hydrochloride (Standard)
  • HY-W040821R
    DL-Homocysteine (Standard) 454-29-5
    Metoprolol acid (Standard) is the analytical standard of Metoprolol acid. This product is intended for research and analytical applications. Metoprolol acid (Atenolol acid) is a urinary metabolite with no pharmacological activity. Metoprolol acid does not exert its pharmacological effects in vivo. Metoprolol acid can be detected by solid phase extraction and reversed phase high performance liquid chromatography. The analysis of metoprolol acid requires specific conditions, such as the use of fluorescence detection and specific eluents.
    DL-Homocysteine (Standard)
  • HY-W040971R
    Creosol (Standard) 93-51-6 98%
    Creosol (Standard) (2-Methoxy-4-methylphenol (Standard)) is the analytical standard of Creosol (HY-W040971). This product is intended for research and analytical applications. Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable.
    Creosol (Standard)
  • HY-W040971S
    Creosol-d4 20189-08-6 98%
    Creosol-d4 (2-Methoxy-4-methylphenol-d4) is the deuterium labeled Creosol (HY-W040971). Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable.
    Creosol-d4
  • HY-W042156R
    Aegeline (Standard) 456-12-2 98%
    Aegeline (Standard) is the analytical standard of Aegeline. This product is intended for research and analytical applications. Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity.
    Aegeline (Standard)
  • HY-W042416R
    N,N-Dimethylacetamide (Standard) 127-19-5 98%
    N,N-Dimethylacetamide (Standard) is the analytical standard of N,N-Dimethylacetamide. This product is intended for research and analytical applications. N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.
    N,N-Dimethylacetamide (Standard)
  • HY-W045132S
    N-Desbutyl bupivacaine-d6 98%
    N-Desbutyl bupivacaine-d6 (Desbutylbupivacaine-d6) is the deuterium labeled N-Desbutyl Bupivacaine (HY-W045132). N-Desbutyl Bupivacaine (compound 100) is a metabolite of Bupivacaine (HY-B0405), an NMDA receptor inhibitor and SCN5A antagonist.
    N-Desbutyl bupivacaine-d6
  • HY-W050088R
    Isoxepac (Standard) 55453-87-7 98%
    Isoxepac (Standard) (HP 549 (Standard)) is the analytical standard of Isoxepac (HY-W050088). This product is intended for research and analytical applications. Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases.
    Isoxepac (Standard)
  • HY-W050088S
    Isoxepac-d6 2012598-71-7 98%
    Isoxepac-d6 (HP 549-d6) is the deuterium labeled Isoxepac (HY-W050088). Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases.
    Isoxepac-d6
  • HY-W073336A
    1-(3-Fluorophenyl)piperazine hydrochloride 76835-10-4 98.03%
    1-(3-Fluorophenyl)piperazine hydrochloride is a 5-HT receptor 1A blocker and an adrenergic receptor blocker.
    1-(3-Fluorophenyl)piperazine hydrochloride
  • HY-W077226S
    AChE-IN-23-d10 98%
    AChE-IN-23-d10 (4-Amino-Alpha-diethyl amino-o-cresol-d10 (dihydrochloride)) is the deuterium labeled AChE-IN-23 (HY-W077226). AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 48.3 μM.
    AChE-IN-23-d10
  • HY-W089856R
    Chlorobutanol hemihydrate (Standard) 6001-64-5
    Chlorobutanol (hemihydrate) (Standard) is the analytical standard of Chlorobutanol (hemihydrate). This product is intended for research and analytical applications. Chlorobutanol hemihydrate is a pharmaceutical preservative. Chlorobutanol hemihydrate is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol hemihydrate is widely used in food and cosmetic industry.
    Chlorobutanol hemihydrate (Standard)
  • HY-W094475D
    Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC 10034-99-8 98%
    Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC (Epsom salts, meets analytical specification of Ph. Eur. BP USP FCC) is currently the anticonvulsant of choice for the prevention and control of eclamptic fits and is also widely used as a tocolytic agent.
    Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC
  • HY-W1015419
    α-FMH 73804-75-8 98%
    α-FMH (α-Fluoromethylhistidine) is an orally active histidine decarboxylase inhibitor. α-FMH depletes histamine in enterochromaffin-like (ECL) cells, reduces the number and volume density of secretory vesicles in ECL cells, and does not affect histamine storage in mast cells. α-FMH abolishes Omeprazole (HY-B0113)-induced vacuolization of ECL cells and decreases gastrin-induced histamine efflux from ECL cells. α-FMH does not alter the granular characteristics of ECL cells, omeprazole-induced hypertrophy of ECL cells, gastrin-induced pancreastatin-like immunoreactivity efflux, nor does it affect gastric acid secretion induced by histamine or vagal stimulation. α-FMH inhibits basal and gastrin-stimulated gastric acid secretion, reduces acid output induced by gastrin+IBMX (HY-12318), but does not directly affect acid generation in isolated parietal cells.
    α-FMH
  • HY-W103105R
    R 29676 (Standard) 53786-28-0 98%
    R 29676 is a neuroleptic agent and inhibits sodium-dependent GABA binding (GABA uptake).
    R 29676 (Standard)
  • HY-W1120833
    m-PEG26-NHS ester
    m-PEG26-NHS ester is a PEG derivative. m-PEG26-NHS ester can be used for the study of Niemann-Pick type C1 disease.
    m-PEG26-NHS ester
  • HY-W1121876
    1-Terpineol 586-82-3
    1-Terpineol is a lipid-soluble monoterpenoid alcohol compound found in Myristica fragrans Houtt.. 1-Terpineol exhibits antibacterial, antioxidant and anti-inflammatory activities.
    1-Terpineol
  • HY-W1121922
    (±)-Mintlactone 13341-72-5 98%
    (±)-Mintlactone is a member of benzofurans that can be found in the essential oil of Menthu piperitu L. (peppermint oil).
    (±)-Mintlactone
  • HY-W1121939
    Perillyl acetate 15111-96-3
    Perillyl acetate is a monoterpene found in in essential oils of plants and is synthesized from perillyl alcohol (HY-N7000). Perillyl acetate can activate the μ-opioid receptor and exert potent analgesic activity. Perillyl acetate can be used for the research of inflammation and neurological disease such as arthritis.
    Perillyl acetate
Cat. No. Product Name / Synonyms Application Reactivity